A. R. Bagheri, C. Laforsch, A. Greiner, S. Agarwal
Global Challenges 2017, 1700048.
The stability of polymers with C[BOND]C and stable C[BOND]heteroatom backbones against chemicals, hydrolysis, temperature, light, and microbes has challenged society with the problem of accumulation of plastic waste and its management worldwide. Given careless disposal of plastic waste, large amounts of plastic litter accumulate in the environment and disintegrate into microplastics.
New Review coauthored by Shaohua Jiang, Seema Agarwal and Andreas Greiner published in Angewandte Chemie
"Low-density open cellular sponges as functional materials''
Welcome to Macromolecular Chemistry II
Spruch der Woche
"Die reinste Form des Wahnsinns ist es, alles beim Alten zu lassen und gleichzeitig zu hoffen, dass sich etwas ändert. (The sheerest madness is to leave everything the way it is and to simultaneously hope that something will change)" Albert Einstein
"The fate of genius is to be misunderstood, but not everything is a misunderstood genius" Ralp Waldo Emmerson (1803-1882)
"Facts do not cease to exist because they are ignored” (Aldous Huxley, author of Brave New World)
"Die Ablehnung Unwichtiges zu tun, ist eine entscheidende Voraussetzung für den Erfolg“ Sir Alexander MacKenzie
"An idea that is not dangerous is unworthy of being called an idea at all“ von Oscar Wilde (Eine Idee, die nicht gewagt ist, verdient es nicht, überhaupt eine Idee genannt zu werden)
G.Duan, A.Reza Bagheri, S.Jiang, J.Golenser, S.Agarwal, A. Greiner
Biomacromolecules 2017 DOI: 10.1021/acs.biomac.7b00852
Achieving high drug loading capacity and controlling drug delivery are two main challenges related to drug carriers. In this study, polymeric macroporous sponges with very high pore volume and large porosity are introduced as a new-type of drug carrier. Due to the high pore volume (285 and 166 cm3/g for the sponges with densities of 3.5 and 6.0 mg/cm3, respectively), the sponges exhibit very high drug loading capacities with average values of 1870 ± 114 and 2697 ± 73 mg/g in the present study, which is much higher than the meso and microporous drug carriers (<1500 mg/g). In order to control the release profiles, an additional poly(p-xylylene) (PPX) coating was deposited by chemical vapor deposition on the drug loaded sponge. Consequently, Artemisone (ART) release in the aqueous medium could be retarded, depending on the density of the sponge and the thickness of the coating. In future, the new 3D polymeric sponges would be highly beneficial as drug carriers for the programmed release of drugs for treatment of chronic diseases.